Space-borne apparatus must maintain a high level of performance and stability throughout the mission duration in the harsh environment of space. The mechanical design must be such that the payload and satellite withstand the significant shocks and vibrations of the launch. The extremes of temperature that may be encountered in space require that the thermal and mechanical designs be such that the sensitive components maintain excellent stability over a broad range of temperatures. The radiation environment in space is a major consideration in the design of electronic circuitry. Electromagnetic interference (EMI) from electronic device must be minimized. Furthermore the instrument must be calibrated at accelerators to verify the design performances.

For these reasons, during the construction phase of the PAMELA subsystems a selection of electronic components, most "off-the-shelf" commercial products, have been tested under gamma at the ENEA-Casaccia (Italy) facilities and under heavy ion beams at GSI in Darmstadt (Germany) and JINR in Dubna (Russia) Laboratories.

Moreover a MASS-Dimensional and Thermal Model (MDTM) was manufactured for Mechanical and Thermal Qualification and a "Technological Model" for Magnetic and Electrical Qualification and for testing the communications with the satellite.
The Flight Model also has been space qualified by mechanical and electrical tests and calibrated at accelerators